Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3H6YC)

Drug Name

G-619 Drug Info

Synonyms

4-Methoxy-N3-(3-picolyl)-1,3-benzenedicarboxamide; 4-Methoxy-N3-(3-pyridylmethyl)-1,3-benzenedicarboxamide

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thromboxane A2 receptor (TBXA2R)	TT2O84V	TA2R_HUMAN	Modulator	[1]
Thromboxane-A synthase (TBXAS1)	TTKNWZ4	THAS_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thromboxane-A synthase (TBXAS1)	DTT	TBXAS1	5.289	4.615	4.413	3.585
Thromboxane A2 receptor (TBXA2R)	DTT	TBXA2R	6.075	5.925	6.729	6.096

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Thrombosis

ICD Disease Classification

DB61-GB90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thromboxane-A synthase (TBXAS1)	DTT	TBXAS1	6.56E-01	0.02	0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	G 619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, inhibits tumor necrosis factor-alpha biosynthesis. Eur J Pharmacol. 1995 Nov 3;286(1):31-9.