General Information of Drug (ID: DM3INUK)

Drug Name
GNF-PF-117 Drug Info
Synonyms
4-Hydroxy-6-methoxy-2-phenylquinoline; 17282-70-1; GNF-PF-117; 6-methoxy-2-phenylquinolin-4-ol; 6-Methoxy-2-phenyl-4-quinolinol; 6-Methoxy-2-phenyl-1H-quinolin-4-one; CHEMBL14120; 6-Methoxy-2-phenyl-quinolin-4-ol; Maybridge3_005419; AC1L3YAP; Oprea1_238017; SCHEMBL6534282; SCHEMBL10610678; CTK8F6034; CTK7A7980; MolPort-000-677-170; KUC100231N; HMS1446G07; ZINC8649323; 2-Phenyl-4-oxy-6-methoxy-chinolin; KUC100231; BDBM50041130; SBB016283; AKOS009868047; AKOS000273771; MCULE-6727803755; AB10684; CCG-252411; IDI1_016806
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
124348
CAS Number
CAS 57183-50-3
TTD Drug ID
DM3INUK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin (TUB) TTML2WA NOUNIPROTAC Inhibitor [1]
Tubulin beta (TUBB) TTYFKSZ NOUNIPROTAC Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tubulin (TUB) DTT TUB 7.743 8.411 8.625 8.347
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tubulin (TUB) DTT NO-GeName 7.94E-02 0.35 0.43
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agent... J Med Chem. 1993 Apr 30;36(9):1146-56.