Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3J5MR)

Drug Name
N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide Drug Info
Synonyms CHEMBL557066; SCHEMBL3292989; SCHEMBL3292983; BDBM50293365
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15986508
TTD Drug ID
DM3J5MR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase 2 (HDAC2) TTSHTOI HDAC2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histone deacetylase 2 (HDAC2) DTT HDAC2 5.815 7.561 7.044 7.334
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histone deacetylase 2 (HDAC2) DTT HDAC2 8.48E-01 -7.29E-04 -4.65E-03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12.