Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3ML0N)

• Drug Name: Tramazoline Drug Info
• Synonyms: Tramazoline; 1082-57-1; UNII-SLE31693IV; Towk; CHEMBL32573; SLE31693IV; QQJLHRRUATVHED-UHFFFAOYSA-N; 4,5-Dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-1H-imidazol-2-amine; Rhinol; 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-; N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine; Tramazolina; Rhynaspray; Tramazolinum; Tobispray; Tramazoline [INN:BAN]; Tramazolinum [INN-Latin]; Tramazolina [INN-Spanish]; Muconasal (TN); EINECS 214-105-6; Tramazoline (INN); TRAMAZOLIN; AC1Q4UQJ; AC1L1KJB

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5524
  ChEBI ID: CHEBI:134893
  CAS Number: CAS 1082-57-1
  TTD Drug ID: DM3ML0N

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

References

• [1] alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401.