Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM46MKY)

Drug Name

2,3-dihydro-1H-indene-5-sulfonamide Drug Info

Synonyms

Indane-5-sulfonamide; indane-5-sulfonamide; 35203-93-1; Indan-5-sulphonamide; Indan-5-sulfonic acid amide; 5-Indansulfonamide; CHEMBL364869; 2,3-dihydro-5-indenylsulfonamide; 2qoa; 5-indanesulfonamide; NSC91508; EINECS 252-432-6; indan-5-sulfonamide; AC1L3XER; AC1Q6UJV; AC1Q55FD; AC1Q55FC; SCHEMBL2011443; CTK7F2159; DTXSID40188710; MolPort-001-845-197; XVQJTFMKKZBBSX-UHFFFAOYSA-N; ZINC394620; HMS3604H17; 1295AE; NSC-91508; BDBM50155556; AKOS000141119; AS-8808; MCULE-2518558267; DB08165; NE29982; Indan-5-sulfonic acid amide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 96876
CAS Number: CAS 35203-93-1
TTD Drug ID: DM46MKY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[3]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[2]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XII (CA-XII)	DTT	CA12	6.015	9.06	10.222	5.773
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase XIV (CA-XIV)	DTT	CA14	6.263	6.538	6.531	6.293
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase XII (CA-XII)	DTT	CA12	3.29E-21	1.27	1.02
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase XIV (CA-XIV)	DTT	CA14	5.79E-07	-0.09	-0.16
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60.
3	Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.