Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4BQFW)

Drug Name
omega-conotoxin GVIA Drug Info
Synonyms
UNII-CA669FO97Q; CA669FO97Q; omega-Cgtx; omega Cgtx; omega-Cgtx gvia; Conus geographus toxin; omega-Ctx; omega Conus geographus toxin; toxin, omega-Conus geographus; omega-Conopeptide gvia; Snx 124; omega-Conotoxin G VIA (reduced); 92078-76-7; GTPL2535; LS-187069
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16133838
ChEBI ID
CHEBI:90630
CAS Number
CAS 106375-28-4
TTD Drug ID
DM4BQFW

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) TTX4QDJ CAC1A_HUMAN Blocker (channel blocker) [2]
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) TT4FDG6 CAC1B_HUMAN Blocker (channel blocker) [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DTT CACNA1B 4.087 2.433 1.632 3.392
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DTT CACNA1B 9.07E-01 7.11E-03 0.06
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2535).
2 Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem. 2000 Nov 10;275(45):35335-44.