Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4NBUH)

Drug Name

1-D-glucopyranosyl cytosine Drug Info

Synonyms

1-D-glucopyranosyl cytosine; CHEMBL1096136; 4-Amino-1-Beta-D-Glucopyranosylpyrimidin-2(1h)-One; 1-D-glucopyranosyl-cytosine; SCHEMBL7520145; 1-beta-D-Glucopyranosylcytosine; BDBM50316588

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21678292
TTD Drug ID: DM4NBUH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glycogen phosphorylase muscle form (GP)	DTT	PYGM	4.036	5.34	6.256	6.062

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glycogen phosphorylase muscle form (GP)	DTT	PYGM	2.69E-01	-0.23	-0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modellin... Bioorg Med Chem. 2010 May 15;18(10):3413-25.