Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4R1MK)

• Drug Name: Isoquinoline derivative 3 Drug Info
• Synonyms: PMID27215781-Compound-24

Indication

Disease Entry	ICD 11	Status	REF
Neuropathic pain	8E43.0	Patented	[1]

• Cross-matching ID:
  PubChem CID: 57525218
  TTD Drug ID: DM4R1MK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Not Available	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cannabinoid receptor 2 (CB2)	DTT	CNR2	7.037	6.733	6.944	7.163

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Neuropathic pain
• ICD Disease Classification: 8E43.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 2 (CB2)	DTT	CNR2	3.82E-02	-0.43	-1.18

References

• [1] Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56.