Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4TSVC)

Drug Name

1-hydroxy-3-phenylurea Drug Info

Synonyms

1-hydroxy-3-phenylurea; Urea, N-hydroxy-N'-phenyl-; Urea, 1-hydroxy-3-phenyl-; 7335-35-5; CHEMBL125955; NSC52953; NSC 52953; WLN: QMVMR; AI3-63229; AC1Q5NHR; SCHEMBL676383; AC1L322W; DTXSID20223597; MolPort-003-699-942; ZINC161805; BDBM50377106; NSC-52953; AKOS024336836

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 81786
CAS Number: CAS 7335-35-5
TTD Drug ID: DM4TSVC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10.