Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4X0SJ)

Drug Name

2-(4,5-dihydro-1H-imidazol-2-yl)quinoline Drug Info

Synonyms

BU 224; 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline; CHEMBL13698; 2-(4,5-Dihydroimidaz-2-yl)-Quinoline; BU-224; NCGC00015130-01; Tocris-0725; Lopac-B-154; AC1L1DPZ; Lopac0_000167; SCHEMBL1526637; CHEBI:92967; CTK5J7405; ZINC2565858; BDBM50240365; CCG-204262; NCGC00024750-02; NCGC00015130-02; NCGC00024750-01; NCGC00015130-03; NCGC00015130-04; 2-(4,5-Dihydro-1H-imidazol-2-yl)-quinoline

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2457
ChEBI ID: CHEBI:92967
CAS Number: CAS 187173-05-3
TTD Drug ID: DM4X0SJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9.