Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM51FVE)

Drug Name

Zamifenacin Drug Info

Synonyms

Zamifenacin; 127308-82-1; UNII-Y88Q418Y7M; Y88Q418Y7M; Zamifenacin [INN]; 127263-13-2; AC1MJ6I5; DSSTox_RID_82215; DSSTox_CID_27257; DSSTox_GSID_47257; SCHEMBL311829; CHEMBL27507; DTXSID9047257; UK-766542 [As Fumarate]; CHEBI:93417; ZINC3802222; BCP28100; Tox21_300210; AKOS022182209; SB19711; API0007427; UK-76654-2 [AS FUMARATE]; NCGC00247932-01; NCGC00254011-01; AJ-45652; CAS-127308-82-1; BRD-K80451230-051-01-8; (R)-3-(Diphenylmethoxy)-1-(3,4-(methylenedioxy)phenetyl)piperidene

Indication

Disease Entry	ICD 11	Status	REF
Urinary incontinence	MF50.2	Discontinued in Phase 3	[1]

Cross-matching ID

PubChem CID: 3086618
ChEBI ID: CHEBI:93417
CAS Number: CAS 127308-82-1
TTD Drug ID: DM51FVE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Urinary incontinence

ICD Disease Classification

MF50.2

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003650)
2	Drug treatment options for irritable bowel syndrome: managing for success. Drugs Aging. 2001;18(3):201-11.