Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM53JXE)

Drug Name
Indomethacin analog 3 Drug Info
Synonyms PMID28895472-Compound-22
Cross-matching ID
PubChem CID
71523527
TTD Drug ID
DM53JXE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dihydrodiol dehydrogenase type I (AKR1C3) TT5ZWB6 AK1C3_HUMAN Inhibitor; Antagonist; Blocker [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dihydrodiol dehydrogenase type I (AKR1C3) DTT AKR1C3 9.375 10.135 10.108 10.14
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dihydrodiol dehydrogenase type I (AKR1C3) DTT AKR1C3 4.06E-01 1.39 0.74
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340.