Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM59JCN)

Drug Name
Drotrecogin alfa Drug Info
Synonyms Xigris; Drotrecogin alfa (activated); Xigris (TN); Drotrecogin alfa (activated) (USAN)
Indication
Disease Entry ICD 11 Status REF
Cerebrovascular ischaemia 8B1Z Approved [1]
Severe sepsis 1G40-1G41 Approved [1]
Therapeutic Class
Antisepsis Agents
Cross-matching ID
TTD Drug ID
DM59JCN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor Va (F5) TT1O264 FA5_HUMAN Inhibitor [2]
Coagulation factor VIII (F8) TT1290U FA8_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Coagulation factor Va (F5) DTT F5 9.187 5.354 5.198 6.174
Coagulation factor VIII (F8) DTT F8 7.637 6.9 7.644 6.975
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cerebrovascular ischaemia
ICD Disease Classification 8B1Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Coagulation factor Va (F5) DTT F5 2.14E-37 1.93 2.54
Coagulation factor VIII (F8) DTT F8 1.08E-22 0.89 1.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6788).
2 Protein C in critical illness. Am J Health Syst Pharm. 2009 Jun 15;66(12):1089-96.