Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5AOFW)

Drug Name
DIGITOXIGENIN Drug Info
Synonyms
Uzarigenin; 466-09-1; UNII-K9ZR7LI283; EINECS 207-373-0; NSC 119993; BRN 0095446; K9ZR7LI283; 3-beta-14-beta-5-Allo-cardenolid [German]; 3beta,14-Dihydroxy-5alpha-card-20(22)-enolide; 3-beta,14-Dihydroxy-5-alpha-card-20(22)-enolide; 4-18-00-01470 (Beilstein Handbook Reference); Urarigenin; Odorigeni; 3-beta-14-beta-5-Allo-cardenolid; AC1L3OS7; CHEMBL109863; SCHEMBL1152953; XZTUSOXSLKTKJQ-CIXPXFMPSA-N; MolPort-006-111-351; ZINC4073972; MCULE-2541512222; NCGC00384854-01; BC271971; 3,14-Dihydroxycard-20(22)-enolide #
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4369270
ChEBI ID
CHEBI:42219
CAS Number
CAS 143-62-4
TTD Drug ID
DM5AOFW
VARIDT Drug ID
DR01376

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium pump subunit alpha-1 (ATP1A1) TTWK8D0 AT1A1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 7.891 11.257 11.348 10.906
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 4.66E-01 1.00E-02 0.06
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 3.31E-01 -0.03 -0.19
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity r... J Med Chem. 2000 Jun 15;43(12):2332-49.