Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5CKVF)

Drug Name
Tetra-hydro-isoquinoline derivative 2 Drug Info
Synonyms PMID29757691-Compound-5b
Cross-matching ID
PubChem CID
46829772
ChEBI ID
CHEMBL4094660
TTD Drug ID
DM5CKVF

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [1]
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [1]
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Monoamine oxidase type B (MAO-B) DTT MAOB 9.367 6.907 8.237 8.409
Monoamine oxidase type A (MAO-A) DTT MAOA 7.207 8.159 9.043 7.711
Acetylcholinesterase (AChE) DTT ACHE 1.678 1.926 1.766 5.252
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type B (MAO-B) DTT MAOB 9.83E-01 0.04 0.19
Monoamine oxidase type A (MAO-A) DTT MAOA 6.93E-01 -0.36 -0.41
Acetylcholinesterase (AChE) DTT ACHE 6.39E-02 -1.07 -1.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.