Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5JQ0D)

Drug Name

Streptokinase Drug Info

Synonyms

Awelysin; Estreptoquinasa; Kabikinase; Streptase; Streptochinasi; Streptokinasum; Streptochinasi [DCIT]; Streptococcal fibrinolysin; Estreptoquinasa [INN-Spanish]; Streptase (TN); Streptokinasum [INN-Latin]; 4-cyclohexylpyrrolidine-2-carboxylic Acid

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary embolism	BB00	Approved	[1]
Acute myocardial infarction	BA41	Phase 4	[2]
Severe acute respiratory syndrome (SARS)	1D65	Discontinued in Phase 3	[3]

Therapeutic Class

Thrombolytic Agents

Cross-matching ID

PubChem CID: 9815560
CAS Number: CAS 9002-01-1
TTD Drug ID: DM5JQ0D

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Activator	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Plasminogen (PLG)	DTT	PLG	11.754	0.848	8.393	2.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Pulmonary embolism

ICD Disease Classification

BB00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Plasminogen (PLG)	DTT	PLG	8.61E-01	-0.01	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
2	ClinicalTrials.gov (NCT00302419) Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT03465085) Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS. U.S. National Institutes of Health.
4	Acute anuric renal failure with streptokinase therapy in a patient with acute venous thromboembolic disease and the review of renal side effects of streptokinase. Tuberk Toraks. 2008;56(4):456-61.