Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5KZ74)

Drug Name
1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Drug Info
Synonyms CHEMBL1086332; 1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea; SCHEMBL13527422
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
46831055
TTD Drug ID
DM5KZ74

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 3A receptor (HTR3A) TTPC4TU 5HT3A_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 3A receptor (HTR3A) DTT HTR3A 5.693 5.728 5.986 6.087
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 3A receptor (HTR3A) DTT HTR3A 6.60E-01 1.08E-02 0.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and... J Med Chem. 2010 Jun 10;53(11):4379-89.