Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5MFHO)

Drug Name
REIC gene therapy Drug Info
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DM5MFHO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dickkopf-related protein 3 (DKK3) TTY2ZV6 DKK3_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dickkopf-related protein 3 (DKK3) DTT DKK3 3.695 6.928 6.737 5.999
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Prostate
The Studied Disease Prostate cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dickkopf-related protein 3 (DKK3) DTT DKK3 4.23E-02 1.81 1.19
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01931046) Study of a Recombinant Adenovirus to Treat Localized Prostate Cancer. U.S. National Institutes of Health.
2 Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer. J Gastroenterol Hepatol. 2014 May;29(5):973-83.