Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6BNQR)

• Drug Name: NORBOLDINE Drug Info
• Synonyms: Laurolitsine; 5890-18-6; Laurolistine; Norboldine; UNII-5MT88IS14F; 1,10-Dimethoxy-6a-alpha-noraporphine-2,9-diol; Dimethoxy-1,10 dihydroxy-2,9 nor-aporphine; 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-; CHEMBL487388; 5MT88IS14F; CHEBI:66557; (6aS)-1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol; Dimethoxy-1,10 dihydroxy-2,9 nor-aporphine [French]; 6a-alpha-NORAPORPHINE-2,9-DIOL, 1,10-DIMETHOXY-; (+)-Norboldine; 568-39-8; [(+)-norboldine]; AC1L2JVN; DTXSID30207641

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 22179
  ChEBI ID: CHEBI:66557
  CAS Number: CAS 5890-18-6
  TTD Drug ID: DM6BNQR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99

References

• [1] Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.