Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6H8JM)

Drug Name

Ro-04-6790 Drug Info

Synonyms

Ro 04-6790; 202466-68-0; Ro-04-6790; CHEMBL433461; Ro-046790; 4-amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide; 4-Amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide; 4-amino-N-(2,6-bis(methylamino)pyrimidin-4-yl)benzenesulfonamide; JELFWSXQTXRMAJ-UHFFFAOYSA-N; Ro 4-6790; NCGC00015885-01; 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide Dihydrobromide; Lopac-R-140; AC1NSM3L; Biomol-NT_000164; Lopac0_001045; GTPL274; SCHEMBL678897; BPBio1_000551; CTK8E8508; CHEBI:92762; ZINC23472

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5312145
ChEBI ID: CHEBI:92762
CAS Number: CAS 202466-68-0
TTD Drug ID: DM6H8JM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 6 receptor (HTR6)	DTT	HTR6	5.594	5.781	5.271	3.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 6 receptor (HTR6)	DTT	HTR6	1.23E-05	-0.12	-0.71

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 274).
2	Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. J Med Chem. 2009 Feb 12;52(3):675-87.