Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6K3JQ)

• Drug Name: COTI-2 Drug Info
• Synonyms: Coti-2; UNII-2BTA1O65BR; 2BTA1O65BR; 1039455-84-9; ZINC114475331; CS-8156; HY-19896; 1-Piperazinecarbothioic acid, 4-(2-pyridinyl)-, 2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide

Indication

Disease Entry	ICD 11	Status	REF
Cervical cancer	2C77.0	Phase 1	[1]
Endometrial cancer	2C76	Phase 1	[1]
Fallopian tube cancer	2C74	Phase 1	[1]
Head and neck cancer	2D42	Phase 1	[1]
Ovarian cancer	2C73	Phase 1	[1]
Peritoneal cavity cancer	2C51.Z	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 91810660
  CAS Number: CAS 1039455-84-9
  TTD Drug ID: DM6K3JQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cellular tumor antigen p53 (TP53)	TT7SBF5	P53_HUMAN	Modulator	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cellular tumor antigen p53 (TP53)	DTT	TP53	5.257	4.938	5.396	5.626

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 02 Neoplasm
• Disease Class: ICD-11: 2C82 Prostate cancer
• The Studied Tissue: Head and neck tissue
• The Studied Disease: Head and neck cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cellular tumor antigen p53 (TP53)	DTT	TP53	1.22E-01	0.22	0.47

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)