Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6KNMB)

Drug Name

3-azageranylgeranyl diphosphate Drug Info

Synonyms

3-Azageranylgeranyl diphosphate; CHEMBL71360; 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE; MGM; 150942-60-2; AC1L9KO8; GTPL3199; DTXSID70332249; BDBM50113289; 3-aza-geranylgeranyl diphosphoric acid; DB08180; 3-aza-geranylgeranyl pyrophosphoric acid; Diphosphoric acid, mono[2-[methyl[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]amino]ethyl] ester (9CI); 2-[methyl-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-amino]-ethyl trihydrogendiphosphate(3-aza-GGPP)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 447278
CAS Number: CAS 150942-60-2
TTD Drug ID: DM6KNMB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Geranyltranstransferase (FDPS)	DTT	FDPS	7.06E-03	-0.73	-2.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3199).
2	Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem. 2002 May 23;45(11):2185-96.