Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6OUW0)

Drug Name

(S)-2-amino-3-(benzylthio)propanoic acid Drug Info

Synonyms

H-D-Cys(Bzl)-OH; 23032-53-3; S-benzyl-D-cysteine; (S)-Benzyl-D-Cys; CHEMBL204162; CCRIS 1971; Alanine, 3-(benzylthio)-, L-; EINECS 221-273-4; (S)-2-AMINO-3-(S-BENZYLTHIO)PROPANOIC ACID; AC1Q5R1B; AC1L2QY5; SCHEMBL1927561; D-Cysteine, S-(phenylmethyl)-; CTK7D0951; MolPort-005-937-279; GHBAYRBVXCRIHT-SECBINFHSA-N; ZINC404299; BDBM50179697; AS-49045; AJ-22311; AX8012175; LS-188299

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 76454
TTD Drug ID: DM6OUW0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	5.083	4.833	5.343	2.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	9.36E-01	-0.03	-0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	2.81E-05	-0.15	-0.68

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.