Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM70HZD)

Drug Name
Zonampanel Drug Info
Synonyms
Zonampanel; Ym 872; 210245-80-0; YM-872; UNII-9X33544ILS; CHEMBL119625; 9X33544ILS; Zonampanel [USAN:INN]; YM872 anhydrous; Zonampanel anhydrous; YM 872 anhydrous; Zonampanel (INN/USAN); AC1L3WN2; SCHEMBL678832; DTXSID50175232; ZINC1891930; BDBM50133599; AKOS030257633; CS-6830; KB-81523; HY-15072; QC-11463; D09035; 2-(7-imidazol-1-yl-6-nitro-2,3-dioxo-4H-quinoxalin-1-yl)acetic acid; 7-(1H-Imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl)acetic acid
Cross-matching ID
PubChem CID
148200
CAS Number
CAS 210245-80-0
TTD Drug ID
DM70HZD

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Inhibitor [1]
Glutamate receptor AMPA 1 (GRIA1) TTVPQTF GRIA1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glutamate receptor AMPA 1 (GRIA1) DTT GRIA1 3.209 3.365 3.194 3.379
Glutamate receptor AMPA (GRIA) DTT GRIA 3.07 2.907 2.945 3.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutamate receptor AMPA 1 (GRIA1) DTT GRIA1 5.12E-02 -0.4 -0.21
Glutamate receptor AMPA 1 (GRIA1) DTT GRIA1 2.97E-01 -4.20E-03 -0.01
Glutamate receptor AMPA (GRIA) DTT NO-GeName 5.94E-02 -0.46 -0.15
Glutamate receptor AMPA (GRIA) DTT NO-GeName 8.64E-01 -0.52 -0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11.