Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM73SC6)

Drug Name

SK509 Drug Info

Synonyms

Tetrachlorosalicylanilide; 7426/7/5; 2,3,4,5-tetrachloro-6-hydroxy-n-phenylbenzamide; AC1L3YOY; C11274; AC1Q3L4M; SCHEMBL999269; CHEBI:9473; CTK2H9174; DTXSID90225265; 2-Hydroxy-3,4,5,6-tetrachlorobenzanilide; 2,3,4,5-tetrachloro-6-hydroxy-N-phenyl-benzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 124579
ChEBI ID: CHEBI:9473
CAS Number: CAS 7426-07-5
TTD Drug ID: DM73SC6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Sporulation kinase A (Bact kinA)	TTJVCG0	KINA_BACSU	Inhibitor	[1]
Coagulation factor Xa (F10)	TTCIHJA	FA10_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Coagulation factor Xa (F10)	DTT	F10	7.763	4.672	3.248	4.609

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor Xa (F10)	DTT	F10	4.84E-02	-0.28	-0.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Histidine kinases as targets for new antimicrobial agents. Bioorg Med Chem. 2002 Apr;10(4):855-67.
2	The design and synthesis of noncovalent factor Xa inhibitors. Curr Top Med Chem. 2001 Jun;1(2):137-49.