Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7CM3F)

Drug Name

N-(3-phenoxypyridin-4-yl)methanesulfonamide Drug Info

Synonyms

CHEMBL148542; N-(3-phenoxy-4-pyridinyl)methanesulfonamide; 180194-78-9; N-(3-phenoxypyridin-4-yl)methanesulfonamide; CTK0E3181; DTXSID30437284; BDBM50120980; N-(3-Phenoxy-4-pyridyl)methanesulfonamide; N-(3-Phenoxy-pyridin-4-yl)-methanesulfonamide; Methanesulfonamide, N-(3-phenoxy-4-pyridinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10244543
CAS Number: CAS 180194-78-9
TTD Drug ID: DM7CM3F

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibi... J Med Chem. 2009 Oct 8;52(19):5864-71.