Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7GDEK)

Drug Name

1-benzylpiperidine hydrochloride Drug Info

Synonyms

1-Benzylpiperidine hydrochloride; 6295-81-4; Piperidine, 1-benzyl-, hydrochloride; 1-Benzyl-Piperidine HCl; Piperidine, 1-(phenylmethyl)-, hydrochloride; AC1L46RA; benzylpiperidine hydrochloride; CHEMBL555311; SCHEMBL7409551; 2905-56-8 (Parent); DTXSID70212153; NSC49527; NSC-49527; LS-114289; KB-218184

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 201590
CAS Number: CAS 6295-81-4
TTD Drug ID: DM7GDEK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31.