Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7XTHD)

Drug Name

Piriqualone Drug Info

Synonyms

SRC 909; BRN 0622820; 1897-90-1; 2-(2-(3-Pyridyl)-ethenyl)-3-(o-tolyl)-4(3H)-quinazolinone; 2-(beta-Pyridyl-(3'')-aethenyl)-3-(o-tolyl)chinazolinone-(4) [German]; 4(3H)-Quinazolinone, 2-(2-(3-pyridyl)ethenyl)-3-(o-tolyl)-; 3-(2-methylphenyl)-2-(2-(3-pyridinyl)ethenyl)-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 3-(2-methylphenyl)-2-(2-(3-pyridinyl)ethenyl)-; SRC-909; AC1NWBSK; AC1Q6E7H; MolPort-001-954-696; MolPort-019-773-808; 2-(beta-Pyridyl-(3'')-aethenyl)-3-(o-tolyl)chinazolinone-(4); ZINC4018972; STK721935

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6015423
CAS Number: CAS 1897-89-8
TTD Drug ID: DM7XTHD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Inhibitor	[1]
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor AMPA 1 (GRIA1)	DTT	GRIA1	3.209	3.365	3.194	3.379
Glutamate receptor AMPA (GRIA)	DTT	GRIA	3.07	2.907	2.945	3.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA 1 (GRIA1)	DTT	GRIA1	1.46E-06	-0.63	-0.78
Glutamate receptor AMPA (GRIA)	DTT	NO-GeName	1.79E-04	-0.69	-0.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antag... Bioorg Med Chem Lett. 2001 Jan 22;11(2):177-81.