Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8E9YS)

• Drug Name: Trans-dimethyl gababutin Drug Info
• Synonyms: ATAGABALIN; 223445-75-8; UNII-JT7957Q2FB; CHEMBL593430; JT7957Q2FB; PD-0200390; 2-[(3S,4S)-1-(aminomethyl)-3,4-dimethylcyclopentyl]acetic acid; trans-dimethyl gababutin; Atagabalin [USAN:INN]; 2-((3S,4S)-1-(Aminomethyl)-3,4-dimethylcyclopentyl)acetic acid; Atagabalin (USAN/INN); SCHEMBL121610; CTK1A0230; BDBM50305887; AKOS030591721; DB12032; AN-5147; CS-0003598; PD 0200390; D09581; ((3S,4S)-1-(Aminomethyl)-3,4-dimethylcyclopentyl)acetic acid; 3,4-trans-2-(1-(aminomethyl)-3,4-dimethylcyclopentyl)acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9794485
  CAS Number: CAS 223445-75-8
  TTD Drug ID: DM8E9YS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	5.083	4.833	5.343	2.536

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	9.36E-01	-0.03	-0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	2.81E-05	-0.15	-0.68

References

• [1] Synthesis and in vivo evaluation of bicyclic gababutins. Bioorg Med Chem Lett. 2010 Jan 15;20(2):461-4.