Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8GUN9)

Drug Name

1-Benzyl-5-phenyl-1H-imidazole Drug Info

Synonyms

1-benzyl-5-phenyl-1H-imidazole; 53704-79-3; 1-benzyl-5-phenylimidazole; SCHEMBL1501929; CHEMBL463582; CTK1G0360; BDBM24655; DTXSID30440036; AWZYHJQWJWUOHS-UHFFFAOYSA-N; AKOS015905520; 4-phenylimidazole (4-PI) derivative, 27; 1H-Imidazole, 5-phenyl-1-(phenylmethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10444038
CAS Number: CAS 53704-79-3
TTD Drug ID: DM8GUN9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25.