Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8K5Z6)

Drug Name

Motexafin lutetium Drug Info

Synonyms

Lutetium texaphyrin; Lu-Tex; Motexafin lutetium < USAN; Optrin (Pharmacyclics); PCI-0123; Antrin (Pharmacyclics, US, US); Lutrin (National Cancer Institute (US), US; Pharmacyclics, , , JP); (PB-7-11-233'2'4)-Bis(acetato-O)[9,10-diethyl-20,21-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-4,15-dimethyl-8,11-imino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanolato-N1,N18,N23,N24

Indication

Disease Entry	ICD 11	Status	REF
Artery stenosis	BD52	Phase 3	[1]

Cross-matching ID

PubChem CID: 3081907
CAS Number: CAS 156436-90-7
TTD Drug ID: DM8K5Z6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostate specific antigen (KLK3)	TTS78AZ	KLK3_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostate specific antigen (KLK3)	DTT	KLK3	2.524	3.991	2.248	4.76

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Artery stenosis

ICD Disease Classification

BD52

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostate specific antigen (KLK3)	DTT	KLK3	2.01E-01	-0.04	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76.