Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8PBEJ)

Drug Name
4-Hydrazinocarbonyl-benzenesulfonamide Drug Info
Synonyms
4-(hydrazinecarbonyl)benzenesulfonamide; 35264-29-0; 4-(hydrazinecarbonyl)benzene-1-sulfonamide; JIDAHYHCQJXNTD-UHFFFAOYSA-N; 4-(hydrazinylcarbonyl)benzenesulfonamide; 4- benzenesulfonamide; 4-HYDRAZINOCARBONYL-BENZENE-SULFONAMIDE; hydrazide 2; p-Sulfamylbenzoic acid hydrazide; AC1L7XIP; CHEMBL180323; SCHEMBL4616920; BDBM12136; CTK4H4135; DTXSID60312358; 4-Sulfamoylbenzoic acid hydrazide; MolPort-000-887-192; ZINC1556993; STK349231; SBB021016; 4376AB; NSC252930; AKOS000305291; MCULE-5832659214
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
318174
CAS Number
CAS 35264-29-0
TTD Drug ID
DM8PBEJ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5.