Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8PNKC)

Drug Name

N-(5-methylthiazol-2-yl)-2-phenylacetamide Drug Info

Synonyms

N-(5-methyl-1,3-thiazol-2-yl)-2-phenylacetamide; AC1NMTHK; CHEMBL425300; MolPort-006-386-848; ZINC3160947; STK408984; AKOS003243303; MCULE-9670423324; ST004442

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5015763
TTD Drug ID: DM8PNKC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
LOX-5 messenger RNA (ALOX5 mRNA)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
LOX-5 messenger RNA (ALOX5 mRNA)	DTT	ALOX5	9.43E-03	0.14	0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6.