Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8QK2O)

Drug Name

5-benzyl-1,3,4-oxadiazole-2(3H)-thione Drug Info

Synonyms

5-benzyl-1,3,4-oxadiazole-2-thiol; 23288-90-6; 5-Benzyl-[1,3,4]oxadiazole-2-thiol; CHEMBL1164364; 5-Benzyl-1,3,4-oxadiazol-2-yl hydrosulfide; 1,3,4-Oxadiazole-2(3H)-thione,5-(phenylmethyl)-; 2-benzyl-1,3,4-oxadiazole-5-thiol; AC1Q7GGP; 5-benzyl-1,3,4-oxadiazole-2(3H)-thione; ChemDiv2_001277; AC1M00UR; SCHEMBL7023603; SCHEMBL11835354; CTK4F1247; DTXSID60365768; MolPort-000-473-148; HMS1649K04; HMS1372M01; ZINC2379869; BDBM50320724; STK498480; CCG-21122; BBL007772; AKOS000100218; AKOS001054851; MCULE-7500395690

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1987817
CAS Number: CAS 23288-90-6
TTD Drug ID: DM8QK2O

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8.