Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM92X7N)

Drug Name

ASN002 Drug Info

Synonyms

POAZPIKWEFFCBP-UHFFFAOYSA-N; GTPL10000; 2-[1-(4-{[4-(4-hydroxypiperazin-1-yl)phenyl]amino}-5-oxo-5H,6H-pyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl]acetonitrile

Indication

Disease Entry	ICD 11	Status	REF
Eczema	EA80-EA89	Phase 2	[1]
Lymphoma	2A80-2A86	Phase 1/2	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]

Cross-matching ID

PubChem CID: 71269142
CAS Number: CAS 1425381-60-7
TTD Drug ID: DM92X7N

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SYK messenger RNA (SYK mRNA)	TT2HUPM	KSYK_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
SYK messenger RNA (SYK mRNA)	DTT	SYK	3.485	4.618	3.954	5.98

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Eczema

ICD Disease Classification

EA80-EA89

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
SYK messenger RNA (SYK mRNA)	DTT	SYK	3.05E-05	0.29	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)