Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM95XR8)

Drug Name

CTCE-9908 Drug Info

Synonyms

Anticancer therapy, Chemokine Therapeutics; CTCE-9908/0019

Indication

Disease Entry	ICD 11	Status	REF
Sarcoma	2A60-2C35	Phase 1/2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 4 (CXCR4)	TTBID49	CXCR4_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-X-C chemokine receptor type 4 (CXCR4)	DTT	CXCR4	7.415	8.304	6.284	6.972

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Sarcoma

ICD Disease Classification

2A60-2C35

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-X-C chemokine receptor type 4 (CXCR4)	DTT	CXCR4	7.10E-15	-0.4	-0.69

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6.