Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM97DJL)

Drug Name

Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester Drug Info

Synonyms

aphs; 209125-28-0; 2-(2-Heptynylthio)phenol Acetate; (2-hept-2-ynylsulfanylphenyl) acetate; CHEMBL345018; o-(Acetophenyl)hept-2-ynyl sulphide; Phenol, 2-(2-heptynylthio)-, acetate; Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester; AC1L1D69; SCHEMBL3842943; DTXSID40175069; ZINC1903162; BDBM50068160; o-(Acetoxyphenyl)hept-2-ynyl sulphide; RT-011298; FT-0669138

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2211
CAS Number: CAS 209125-28-0
TTD Drug ID: DM97DJL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18.