Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9AEF0)

Drug Name

4-(4-chlorobenzyl)phthalazin-1(2H)-one Drug Info

Synonyms

53242-88-9; 4-(4-chlorobenzyl)phthalazin-1(2H)-one; 4-(4-Chloro-benzyl)-2H-phthalazin-1-one; 4-[(4-chlorophenyl)methyl]-2H-phthalazin-1-one; UNII-56DW142LLX; MLS000547504; 4-(4-chlorobenzyl)phthalazin-1-ol; CHEMBL63976; 4-(4-chlorobenzyl)-1(2H)-phthalazinone; 56DW142LLX; 4-[(4-CHLOROPHENYL)METHYL]PHTHALAZIN-1(2H)-ONE; SMR000113649; 4-(4-Chlorobenzyl)-2H-phthalazin-1-one; 4-[(4-Chlorophenyl)methyl]-1(2H)-phthalazinone; 4-((4-Chlorophenyl)methyl)phthalazin-1(2H)-one; W-109042; 4-{[4-chlorophenyl]methyl}-1(2H)-phthalazinone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 104452
CAS Number: CAS 53242-88-9
TTD Drug ID: DM9AEF0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90.