Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9FMUE)

Drug Name

1,2-bis(2-fluorophenyl)ethane-1,2-dione Drug Info

Synonyms

1,2-bis(2-fluorophenyl)ethane-1,2-dione; CHEMBL244633; 573-43-3; Bis(2-fluorophenyl) diketone; SCHEMBL2156696; CTK1F2289; DTXSID60453098; Ethanedione, bis(2-fluorophenyl)-; ZINC28713881; BDBM50209423; AKOS030595584; 1,2-bis(2-fluorophenyl)-1,2-ethanedione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11043027
CAS Number: CAS 573-43-3
TTD Drug ID: DM9FMUE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17.