Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9LVR5)

Drug Name

3-(5-Thiophen-3-yl-pyridin-3-yl)-1H-indole Drug Info

Synonyms

3-(5-Thien-3-ylpyridin-3-yl)-1Hindole 3a; AC1NS6N5; SCHEMBL7506919; BDBM5318; CHEMBL327518; 3-[5-(3-Thienyl)-3-pyridinyl]-1H-indole; 3-(5-thiophen-3-ylpyridin-3-yl)-1H-indole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5329361
TTD Drug ID: DM9LVR5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 2 (KDR)	DTT	KDR	1.98E-01	0.11	0.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2973-6.