Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9T6MS)

Drug Name

Tecadenoson Drug Info

Synonyms

CVT-510; 204512-90-3; UNII-GZ1X96601Z; CHEMBL392149; GZ1X96601Z; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol; BDBM50224766; Tecadenoson [USAN:INN]; Tecadenoson (USAN/INN); AC1L4KMO; SCHEMBL246787; GTPL5592; CHEMBL356254; DTXSID80174415; BDBM50138530; DB04954; N6-[3-(R)-tetrahydrofuranyl]adenosine; HY-19661; Adenosine, N-(3R)-tetrahydro-3-furanyl-; LS-190860; Adenosine, N-(3R)-tetrahydro-3-furanyl)-; CS-0016174; D06019; CVT-510; N-(3-Tetrahydrofuranyl)-6-aminopurine riboside; Selenocompounds

Indication

Disease Entry	ICD 11	Status	REF
Atrial fibrillation	BC81.3	Discontinued in Phase 3	[1]
Cardiac arrhythmias	BC9Z	Discontinued in Phase 3	[1]

Cross-matching ID

PubChem CID: 158795
CAS Number: CAS 204512-90-3
TTD Drug ID: DM9T6MS
VARIDT Drug ID: DR00923

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Agonist	[2]
Protein kinase C (PRKC)	TTYVX59	NOUNIPROTAC	Binder	[3]

------------------------------------------------------------------------------------

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Discontinued in Phase 3	[4]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adenosine A1 receptor (ADORA1)	DTT	ADORA1	4.698	5.291	5.298	4.797
Equilibrative nucleoside transporter 1 (SLC29A1)	DTP	ENT1	6.521	5.997	5.97	5.897

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Atrial fibrillation

ICD Disease Classification

BC81.3

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Equilibrative nucleoside transporter 1 (SLC29A1)	DTP	ENT1	7.28E-01	1.90E-01	3.49E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5592).
2	CV Therapeutics. Company report from CV Therapeutics, Inc. CV Therapeutics. 2009.
3	Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001;40(1):55-63.
4	Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22.