Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9UZD7)

Drug Name
Bile acid Drug Info
Synonyms Bile Salts; Bile acid; Bile salt; CHEBI:22868
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
439520
ChEBI ID
CHEMBL22868
TTD Drug ID
DM9UZD7
INTEDE Drug ID
DR2509

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
G-protein coupled bile acid receptor 1 (GPBAR1) TTSDVTR GPBAR_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 7A1 (CYP7A1) DEDZRQ1 CP7A1_HUMAN Phase 1 [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
G-protein coupled bile acid receptor 1 (GPBAR1) DTT GPBAR1 4.60E-01 0.02 0.09
Cytochrome P450 7A1 (CYP7A1) DME CYP7A1 9.79E-01 -7.86E-01 -3.93E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21.
2 FGF15 activates Hippo signaling to suppress bile acid metabolism and liver tumorigenesis. Dev Cell. 2019 Feb 25;48(4):460-474.e9.