Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAN21O)

Drug Name

VG-101 Drug Info

Synonyms

Seala; VG-101 analogs, Bionovo; Estrogen receptor beta selective agonists (topical intravaginal gel, vaginal dryness), Bionovo; VG-101 (topical intravaginal gel, vaginal dryness), Bionovo

Indication

Disease Entry	ICD 11	Status	REF
Menopause symptom	GA30.0	Phase 1/2	[1]

Cross-matching ID

TTD Drug ID: DMAN21O

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor beta (ESR2)	TTOM3J0	ESR2_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Estrogen receptor beta (ESR2)	DTT	ESR2	3.365	3.776	3.485	3.036

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Menopause symptom

ICD Disease Classification

GA30.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Estrogen receptor beta (ESR2)	DTT	ESR2	2.09E-01	-0.06	-0.17

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00453089) VG101 Phase I/II to Treat Vulvar and Vaginal Atrophy in Post-Menopausal Women. U.S. National Institutes of Health.
2	Update on alternative therapies for vulvovaginal atrophy. Patient Prefer Adherence. 2011; 5: 533-536.