Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMANEH2)

Drug Name

AE-9C90CB Drug Info

Synonyms

Muscarinic M3 antagonists (urinary incontinence); RBx-7643; RBx-8444; RBx-9611; Muscarinic M3 antagonists (urinary incontinence), Daiichi Sankyo; Muscarinic M3 antagonists (urinary incontinence), Ranbaxy

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMANEH2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Antagonist	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Overactive bladder

ICD Disease Classification

GC50.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8586).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 15).