Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMANTW0)

Drug Name

N-Hydroxy-N-methyl-3-naphthalen-2-yl-acrylamide Drug Info

Synonyms

CHEMBL63882; N-Hydroxy-N-methyl-3-naphthalen-2-yl-acrylamide; BDBM50015178; ZINC26247459; N-Methyl-N-hydroxy-2-naphthaleneacrylamide; (E)-N-hydroxy-N-methyl-3-(naphthalen-2-yl)acrylamide; (E)-3-(2-Naphthalenyl)-N-methyl-2-propenehydroxamic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 13687210
TTD Drug ID: DMANTW0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. J Med Chem. 1987 Nov;30(11):2121-6.