Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAO7DS)

Drug Name

2-Sulfamoyl-benzoic acid methyl ester Drug Info

Synonyms

57683-71-3; Methyl 2-(aminosulfonyl)benzoate; methyl 2-sulfamoylbenzoate; 2-Carbomethoxybenzenesulfonamide; (2-Methoxycarbonyl)benzene sulfonamide; 2-Sulfamoylbenzoic acid methyl ester; Methyl o-sulphamoylbenzoate; Benzoic acid, 2-(aminosulfonyl)-, methyl ester; EINECS 260-903-2; BENZOIC ACID, 2-SULFAMOYL-, METHYL ESTER; BRN 2728611; 2-aminosulfonyl-benzoic acid methyl ester; CHEMBL148680; CHEBI:83512; 2-methoxycarbonylphenylsulfonamide; VSOOBQALJVLTBH-UHFFFAOYSA-N; MFCD00009808; 2-(methoxycarbonyl)benzenesulphonamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 42546
ChEBI ID: CHEBI:83512
CAS Number: CAS 57683-71-3
TTD Drug ID: DMAO7DS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5.