Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAPWC2)

Drug Name

H-Leu-Phe-NH2 Drug Info

Synonyms

Leucyl-phenylalanine amide; H-Leu-Phe-NH2; L-Leucyl-L-phenylalaninamide; 38678-60-3; CHEMBL590518; Leu-phe-NH2; AC1MIYXY; SCHEMBL2184039; L-Phenylalaninamide, L-leucyl-; DTXSID30191975; HVNQCDIUFGAINF-STQMWFEESA-N; ZINC1605748; BDBM50308392; AKOS027447855; (2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-3-phenylpropanamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3082491
CAS Number: CAS 38678-60-3
TTD Drug ID: DMAPWC2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Substance-P receptor (TACR1)	TTZPO1L	NK1R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Substance-P receptor (TACR1)	DTT	TACR1	3.597	4.186	4.271	5.113

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Substance-P receptor (TACR1)	DTT	TACR1	7.40E-01	0.02	0.07
Substance-P receptor (TACR1)	DTT	TACR1	8.57E-01	-0.02	-0.18

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9.