Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAQYRL)

Drug Name
Eptacog alfa Drug Info
Synonyms Alfa; Eptacog alfa (GlycoPEGylation, intravenous, hemophilia), Novo Nordisk; Eptacog alfa (GlycoPEGylation, subcutaneous, hemophilia), Novo Nordisk
Indication
Disease Entry ICD 11 Status REF
Hemophilia 3B10.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMAQYRL

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor VII (F7) TTF0EGX FA7_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Coagulation factor VII (F7) DTT F7 9.218 4.853 5.6 5.747
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hemophilia
ICD Disease Classification 3B10.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Coagulation factor VII (F7) DTT F7 2.52E-01 -0.03 -0.19
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02084810) Investigating the Bioequivalence of Eptacog Alfa A 6 mg and NovoSeven in Healthy Male Subjects. U.S. National Institutes of Health.
2 Recombinant factor VIIa (eptacog alfa): a review of its use in congenital hemophilia with inhibitors, acquired hemophilia, and other congenital bleeding disorders. BioDrugs. 2008;22(2):121-36.