Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAT7VN)

Drug Name

3-(4-Benzoylpiperazine-1-carbonyl)coumarin Drug Info

Synonyms

CHEMBL453852; 3-(4-Benzoyl-piperazine-1-carbonyl)-chromen-2-one; 3-(4-Benzoylpiperazine-1-carbonyl)coumarin; Oprea1_255077; Oprea1_655896; MLS001221424; MolPort-000-517-247; ZINC887160; HMS2917O18; HMS1690L15; BDBM50244614; AKOS000599038; MCULE-2543571988; SMR000611504; BAS 02911887; ST50014713; 3-{[4-(phenylcarbonyl)piperazinyl]carbonyl}chromen-2-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1143426
TTD Drug ID: DMAT7VN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acetylcholinesterase (AChE)	DTT	ACHE	1.678	1.926	1.766	5.252

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21.