Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMATB8H)

Drug Name

2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide Drug Info

Synonyms

CHEMBL23285; 2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide; 103826-87-5; AC1MBHEI; Oprea1_396828; p-pivaloylaminobenzenesulfonamide; Propanamide, N-[4-(aminosulfonyl)phenyl]-2,2-dimethyl-; N-(4-Sulfamoylphenyl)Pivalamide; SCHEMBL10603454; ZINC73524; BDBM16649; aromatic sulfonamide compound 14; CCG-916; KGBTVIQRHXYTRQ-UHFFFAOYSA-N; 4-Pivaloylamido-benzenesulfonamide; MolPort-002-912-681; AKOS003441276; MCULE-2674794031; BRD-K77020128-001-01-6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2725651
TTD Drug ID: DMATB8H

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XII (CA-XII)	DTT	CA12	6.015	9.06	10.222	5.773
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase XII (CA-XII)	DTT	CA12	3.29E-21	1.27	1.02
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.